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Toll-like receptor 4 and CD14 polymorphisms in ankylosing spondylitis: evidence of a weak association in Finns.
- Source :
-
The Journal of rheumatology [J Rheumatol] 2008 Aug; Vol. 35 (8), pp. 1609-12. Date of Electronic Publication: 2008 Jul 15. - Publication Year :
- 2008
-
Abstract
- Objective: To investigate the association of CD14 and Toll-like receptor (TLR4) with ankylosing spondylitis (AS).<br />Methods: A promoter variant in CD14 and 2 coding polymorphisms in TLR4 were investigated in UK and Finnish families with AS and in a UK case-control study. A metaanalysis of published TLR4 and CD14 studies was performed.<br />Results: In the Finnish study the CD14-260bp T variant showed an association (p = 0.006), and the common 2-marker TLR4 haplotype showed a weak association (global p = 0.03), with AS. No associations were seen in the UK based studies or in the metaanalyses.<br />Conclusion: CD14 and TLR4 showed an association with AS in the Finns only.
Details
- Language :
- English
- ISSN :
- 0315-162X
- Volume :
- 35
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 18634146