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Prognostic value of primary tumor volume after concurrent chemoradiation with daily low-dose cisplatin for advanced-stage head and neck carcinoma.
- Source :
-
Head & neck [Head Neck] 2008 Sep; Vol. 30 (9), pp. 1216-23. - Publication Year :
- 2008
-
Abstract
- Background: The purpose of this study was to evaluate the prognostic value of tumor volume in head and neck squamous cell carcinoma treated with chemoradiation.<br />Methods: Forty-six patients were treated with radiotherapy and cisplatin (6 mg/m(2) IV x 20, daily). Baseline primary tumor volume was recorded from MRI scans. The prognostic impact of tumor volume and other factors for locoregional control, disease-free survival (DFS), and overall survival (OS) was tested.<br />Results: Mean tumor volume was 28 cm(3) (median 23 cm(3); range, 3-112). The locoregional control rate at 3 years was 81% for patients with tumor volumes <median compared to 48% for tumor volumes > or = median (p = .036). At multivariate analysis, it appeared that tumor volume remained an independent determinant of locoregional control and survival when adjusted for other factors.<br />Conclusions: In advanced-stage head and neck squamous cell carcinoma treated with concurrent chemoradiation, primary tumor volume is associated with locoregional control and survival. Larger studies are needed to confirm whether incorporation of tumor volume in the staging system improves prediction of treatment outcome and can serve as a tool to guide treatment options.
- Subjects :
- Analysis of Variance
Carcinoma, Squamous Cell mortality
Chemotherapy, Adjuvant
Combined Modality Therapy
Disease-Free Survival
Dose-Response Relationship, Drug
Drug Administration Schedule
Evaluation Studies as Topic
Female
Head and Neck Neoplasms mortality
Humans
Kaplan-Meier Estimate
Male
Neoplasm Staging
Prognosis
Proportional Hazards Models
Prospective Studies
Radiotherapy Dosage
Radiotherapy, Adjuvant
Registries
Risk Assessment
Sensitivity and Specificity
Survival Analysis
Treatment Outcome
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell therapy
Cisplatin administration & dosage
Head and Neck Neoplasms pathology
Head and Neck Neoplasms therapy
Tumor Burden
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 30
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 18642295
- Full Text :
- https://doi.org/10.1002/hed.20865