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Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Aug 15; Vol. 18 (16), pp. 4700-4. Date of Electronic Publication: 2008 Jul 05. - Publication Year :
- 2008
-
Abstract
- The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed.
- Subjects :
- Area Under Curve
Benzoxazines pharmacology
Crystallography, X-Ray methods
Drug Design
Humans
Inflammation
Inhibitory Concentration 50
Models, Chemical
Molecular Structure
Protein Isoforms
Structure-Activity Relationship
Benzoxazines chemistry
Chemistry, Pharmaceutical methods
Oxazines chemical synthesis
Oxazines pharmacology
Phosphatidylinositol 3-Kinases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18644721
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.06.104