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Complementary strategies to elucidate T helper cell epitopes in myasthenia gravis.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2008 Sep 15; Vol. 201-202, pp. 41-9. Date of Electronic Publication: 2008 Jul 22. - Publication Year :
- 2008
-
Abstract
- CD4(+) T cells specific for the acetylcholine receptor (AChR) are assumed to play an important role in pathogenesis of myasthenia gravis (MG). A large and diverse number of potential T cell epitopes have been reported for different experimental setups aiming at the identification of disease-relevant T cells in MG. Investigating the T cell response to the epsilon subunit of human AChR, we explore complementary in vitro and in vivo approaches (PBMC from MG patients and mice transgenic for HLA-DR3 and human CD4) to address the possibilities and limitations of different strategies for elucidating natural autoimmune T cell epitopes.
- Subjects :
- Amino Acid Sequence
Animals
Apolipoprotein B-100 pharmacology
CD4 Antigens genetics
Dose-Response Relationship, Drug
HLA-DR3 Antigen genetics
Humans
Mice
Mice, Transgenic
Myasthenia Gravis blood
Peptide Fragments immunology
Protein Binding drug effects
Receptors, Nicotinic immunology
Receptors, Nicotinic metabolism
Epitope Mapping
Epitopes physiology
Myasthenia Gravis pathology
Receptors, Nicotinic chemistry
T-Lymphocytes, Helper-Inducer immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0165-5728
- Volume :
- 201-202
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 18649950
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2008.06.010