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Utility assessment of HIV/AIDS-related health states in HIV-infected Ugandans.
- Source :
-
AIDS (London, England) [AIDS] 2008 Jul; Vol. 22 Suppl 1, pp. S123-30. - Publication Year :
- 2008
-
Abstract
- Objective: To assess the psychometric performance of using standard gamble (SG), time trade-off (TTO) and visual analogue scale (VAS) in the evaluation of three predetermined HIV/AIDS health states in HIV-infected Ugandans, for use in cost-effectiveness analyses.<br />Methods: We recruited participants with CD4 cells <200/microl from the Development of AntiRetroviral Therapy in Africa (DART) trial cohort [randomized trial evaluating antiretroviral therapy (ART) management strategies] in Uganda, before they initiated ART (n = 276). A comparison group of ART-naive HIV-infected individuals was recruited from the Entebbe Cohort study (n = 159). Participants were interviewed and asked to rate his/her own health state using VAS; rank and evaluate HIV/AIDS predetermined health states using TTO and SG relative to an improved health state. Tools were tested for psychometrical properties.<br />Results: Women constituted 64% and 76% of the DART and Entebbe Cohorts. Mean age was 36.5 and 36.7 years, respectively. Participants could discriminate between predetermined HIV/AIDS health states. Deterioration in health status was associated with a reduction in rating scores (VAS), increased willingness to give up time (TTO) and acceptance of increased risk (SG) to achieve a better health state, independent of the participant's actual health state, as measured by CD4 cell counts.<br />Conclusion: VAS, TTO and SG have good psychometric properties, making them good candidates for use in resource-constrained settings. Further research in a wider population is necessary to generate an evidence base with which to inform resource allocation decisions.
- Subjects :
- Adult
Anti-Retroviral Agents economics
Anti-Retroviral Agents therapeutic use
CD4 Lymphocyte Count
Case-Control Studies
Cost-Benefit Analysis
Female
HIV Infections drug therapy
HIV Infections economics
Humans
Male
Psychometrics
Quality of Life
Quality-Adjusted Life Years
Uganda
HIV Infections psychology
Health Status
Sickness Impact Profile
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5571
- Volume :
- 22 Suppl 1
- Database :
- MEDLINE
- Journal :
- AIDS (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 18664944
- Full Text :
- https://doi.org/10.1097/01.aids.0000327633.85221.9a