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Cytokine pattern and endothelium damage markers in Henoch-Schönlein purpura.
- Source :
-
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2008; Vol. 30 (3), pp. 623-9. - Publication Year :
- 2008
-
Abstract
- In a longitudinal cohort study our aim was to evaluate the cytokine pattern of children affected by Henoch-Schonlein purpura (HSP) and to correlate this pattern to vascular endothelium damage and to nephropathy. The following parameters were monitored at the onset of the disease (T0) and after 6 months of follow-up (T1): clinical scores, serum levels of tumor necrosis factor alpha (TNF-alpha), interleukin 2 (IL-2), soluble IL-2 receptor (IL-2sRalpha), fibrinogen, von Willebrand factor antigen (vWf:Ag) and soluble thrombomodulin (TMD) levels. A total of 24 children (9 M, 15 F), affected by HSP, aged between 3-14 years (median 6 years), were enrolled into the study. IL-2 serum levels were significantly increased at the onset of the disease compared to control group and T1. The same pattern was observed for IL-2sRalpha and TNF-alpha. Fibrinogen and vWf:Ag concentrations were significantly higher at the onset of disease than t1 and in control group. TMD levels resulted constantly within the normal range. Concerning the analyzed parameters, no significant difference resulted to be in subjects with and without renal involvement (hematuria and/or proteinuria). Finally, raised serum TNF-alpha concentration, related to vascular endothelium damage as shown by increased vWf:Ag levels, occurred invariably in children affected by HSP both with and without renal involvement.
- Subjects :
- Adolescent
Biomarkers blood
Case-Control Studies
Child
Child, Preschool
Endothelium, Vascular immunology
Endothelium, Vascular metabolism
Female
Fibrinogen metabolism
Hematuria immunology
Hematuria pathology
Humans
IgA Vasculitis complications
IgA Vasculitis metabolism
IgA Vasculitis pathology
Interleukin-2 blood
Interleukin-2 Receptor alpha Subunit blood
Longitudinal Studies
Male
Proteinuria immunology
Proteinuria pathology
Thrombomodulin blood
Tumor Necrosis Factor-alpha blood
Up-Regulation
von Willebrand Factor metabolism
Cytokines blood
Endothelium, Vascular pathology
IgA Vasculitis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2513
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunopharmacology and immunotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 18668398
- Full Text :
- https://doi.org/10.1080/08923970801973646