[Clinical examination of doripenem for infectious diseases in gynecological and associated fields].

We examined the efficacy of doripenem (DRPM), a carbapenem antimicrobial agent, against infectious diseases in gynecological and associated fields, as well as its safety. The following results were obtained: 1) The subjects were 20 patients with infection in the absence of pregnancy and 4 patients with pregnancy/puerperal infection. Intravenous drip of DRPM at 0.25 g x 2/day was performed for 3 to 8 days. The total doses ranged from 1.5 to 4.0 g. 2) Concerning its clinical efficacy, a complete response was achieved in 4 (16.7%) of the 24 patients, and a partial response in 18 (75.0%). The response rate was 91.7% (22/24). In 6 patients who did not respond to the previous agent, the response rate was 100% (6/6). 3) Concerning its clinical efficacy with respect to clinically isolated bacteria, a complete response was achieved in 3 (10.0%) of the 30 strains, and a partial response in 26 (86.7%). Bacteria disappeared in 29 (96.7%) of the 30 strains. 4) There were no side effects nor abnormalities in the laboratory data related to this agent. These results suggest the usefulness of DRPM in the treatment of gynecological infectious diseases.