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[Anthracycline antibiotics and their derivatives--inhibitors of topoisomerase I].
[Anthracycline antibiotics and their derivatives--inhibitors of topoisomerase I].
- Source :
-
Bioorganicheskaia khimiia [Bioorg Khim] 2008 May-Jun; Vol. 34 (3), pp. 430-2. - Publication Year :
- 2008
-
Abstract
- The relationship between the structure of new semisynthetic derivatives of doxorubicin, daunorubicin, and carminomycin and their ability to inhibit topoisomerase 1 were studied. The new derivatives inhibit the activity of topoisomerase 1 at low concentrations, induce the death of K-562 leukemia cells in culture, and produce an antitumor effect in experimental animals with P388 leukemia.
- Subjects :
- Animals
Carubicin pharmacology
Daunorubicin pharmacology
Doxorubicin pharmacology
Drug Screening Assays, Antitumor
Humans
K562 Cells
Leukemia P388 drug therapy
Mice
Structure-Activity Relationship
Carubicin analogs & derivatives
Carubicin chemistry
Daunorubicin analogs & derivatives
Daunorubicin chemistry
Doxorubicin analogs & derivatives
Doxorubicin chemistry
Topoisomerase I Inhibitors
Subjects
Details
- Language :
- Russian
- ISSN :
- 0132-3423
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganicheskaia khimiia
- Publication Type :
- Editorial & Opinion
- Accession number :
- 18672696
- Full Text :
- https://doi.org/10.1134/s1068162008030230