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[Anthracycline antibiotics and their derivatives--inhibitors of topoisomerase I].

[Anthracycline antibiotics and their derivatives--inhibitors of topoisomerase I].

Authors :
Dezhenkova LG
Teviashova AN
Olsuf'eva EN
Treshchalin ID
Shtil' AA
Preobrazhenskaia MN
Source :
Bioorganicheskaia khimiia [Bioorg Khim] 2008 May-Jun; Vol. 34 (3), pp. 430-2.
Publication Year :
2008

Abstract

The relationship between the structure of new semisynthetic derivatives of doxorubicin, daunorubicin, and carminomycin and their ability to inhibit topoisomerase 1 were studied. The new derivatives inhibit the activity of topoisomerase 1 at low concentrations, induce the death of K-562 leukemia cells in culture, and produce an antitumor effect in experimental animals with P388 leukemia.

Details

Language :
Russian
ISSN :
0132-3423
Volume :
34
Issue :
3
Database :
MEDLINE
Journal :
Bioorganicheskaia khimiia
Publication Type :
Editorial & Opinion
Accession number :
18672696
Full Text :
https://doi.org/10.1134/s1068162008030230