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Synthesis and biological screening of aminothiadiazine dioxides related to trimethoprim.
- Source :
-
Arzneimittel-Forschung [Arzneimittelforschung] 1991 Mar; Vol. 41 (3), pp. 264-6. - Publication Year :
- 1991
-
Abstract
- New derivatives of 3-amino-1,2,6-thiadiazine 1,1-dioxide have been synthesized and their antibacterial, antifungal and DHFR inhibitory activities evaluated. Their chemical structures have been established by means of analytical and NMR spectroscopic data. Among the compounds studied, the 4,4-dibromo derivative 11 showed fungistatic activity against C. albicans.
- Subjects :
- Animals
Anti-Bacterial Agents
Anti-Infective Agents chemistry
Anti-Infective Agents pharmacology
Bacteria drug effects
Candida albicans drug effects
Cattle
Folic Acid Antagonists
Liver enzymology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Thiadiazines chemistry
Thiadiazines pharmacology
Trimethoprim chemical synthesis
Trimethoprim pharmacology
Anti-Infective Agents chemical synthesis
Thiadiazines chemical synthesis
Trimethoprim analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0004-4172
- Volume :
- 41
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Arzneimittel-Forschung
- Publication Type :
- Academic Journal
- Accession number :
- 1867665