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Second cancers in children treated with modern radiotherapy techniques.
- Source :
-
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology [Radiother Oncol] 2008 Nov; Vol. 89 (2), pp. 135-40. Date of Electronic Publication: 2008 Aug 15. - Publication Year :
- 2008
-
Abstract
- Background and Purpose: The scattered radiation from the treatment volume might be more significant for children than for adults and, as a consequence, modern radiotherapy treatment techniques such as IMRT and passive proton therapy could potentially increase the number of secondary cancers. In this report, secondary cancer risk resulting from new treatment technologies was estimated for an adult prostate patient and a child.<br />Material and Methods: The organ equivalent dose (OED) concept with a linear-exponential, a plateau and a linear dose-response curve was applied to dose distributions of an adult prostate patient and a child with a rhabdomyosarcoma of the prostate. Conformal radiotherapy, IMRT with 6MV photons and proton therapy were planned. OED (cancer risk) was estimated for the whole body, the rectum and the bladder. In addition, relative cumulative risk was calculated.<br />Results: Secondary cancer risk in the adult is not more than 15% it increased when IMRT or passive proton therapy was compared to conventional treatment planning. In the child, risk remains practically constant or was even reduced for proton therapy. The cumulative risk in the child relative to that in the adult can be as large as 10-15.<br />Conclusions: By a comparison between an adult patient and a child treated for a disease of the prostate, it was shown that modern radiotherapy techniques such as IMRT and proton therapy (active and passive) do not increase the risk for secondary cancers.
- Subjects :
- Dose Fractionation, Radiation
Dose-Response Relationship, Radiation
Humans
Infant
Male
Middle Aged
Radiation Dosage
Radiotherapy adverse effects
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Rectum radiation effects
Risk Assessment
Scattering, Radiation
Urinary Bladder radiation effects
Whole-Body Counting
Neoplasms, Radiation-Induced prevention & control
Prostatic Neoplasms radiotherapy
Radiotherapy methods
Rhabdomyosarcoma radiotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 0167-8140
- Volume :
- 89
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 18707783
- Full Text :
- https://doi.org/10.1016/j.radonc.2008.07.017