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SARS coronavirus and apoptosis.
- Source :
-
Hong Kong medical journal = Xianggang yi xue za zhi [Hong Kong Med J] 2008 Aug; Vol. 14 Suppl 4, pp. 8-13. - Publication Year :
- 2008
-
Abstract
- 1. The adenovirus-mediated overexpression of SARS coronavirus (SARS-CoV) spike protein (S) and its C-terminal domain (S2) induce apoptosis in Vero E6 cells. 2. Such apoptosis in Vero E6 cells is time- and dose-dependent. 3. The adenovirus-mediated overexpression of SARS-CoV N-terminal domain (S1) and other structural proteins, including E,M and N protein, do not induce apoptosis.
- Subjects :
- Adenoviridae genetics
Animals
Apoptosis physiology
Cell Death genetics
Cell Proliferation
Cells, Cultured
Chlorocebus aethiops
Membrane Glycoproteins genetics
Membrane Glycoproteins metabolism
Probability
Severe acute respiratory syndrome-related coronavirus physiology
Sensitivity and Specificity
Severe Acute Respiratory Syndrome genetics
Spike Glycoprotein, Coronavirus
Transduction, Genetic
Vero Cells cytology
Viral Envelope Proteins genetics
Viral Envelope Proteins metabolism
Viral Structural Proteins genetics
Viral Structural Proteins metabolism
Adenoviridae metabolism
Apoptosis genetics
Gene Expression Regulation, Viral
Severe acute respiratory syndrome-related coronavirus genetics
Severe Acute Respiratory Syndrome virology
Subjects
Details
- Language :
- English
- ISSN :
- 1024-2708
- Volume :
- 14 Suppl 4
- Database :
- MEDLINE
- Journal :
- Hong Kong medical journal = Xianggang yi xue za zhi
- Publication Type :
- Academic Journal
- Accession number :
- 18708667