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Tetrahdroxysqualene from Rhus taitensis shows antimycobacterial activity against Mycobacterium tuberculosis.
- Source :
-
Journal of natural products [J Nat Prod] 2008 Sep; Vol. 71 (9), pp. 1623-4. Date of Electronic Publication: 2008 Aug 19. - Publication Year :
- 2008
-
Abstract
- Tuberculosis has become a major health problem, in particular with the emergence of extremely drug resistant tuberculosis (XDRTB). In our search for new therapeutic leads against TB, we isolated a new triterpene (1) from the plant Rhus taitensis collected in Papua New Guinea. Tetrahydroxysqualene (1) was isolated using bioassay-guided fractionation of the methanolic extract of R. taitensis leaves and twigs. The structure of tetrahydroxysqualene (1) was elucidated on the basis of HRESIMS and 1D and 2D NMR spectra. Tetrahydroxysqualene (1) exhibited antituberculosis activity with an MIC of 10.0 microg/mL, while showing only modest cytotoxicity.
- Subjects :
- Drug Resistance, Bacterial drug effects
Drug Screening Assays, Antitumor
Humans
Microbial Sensitivity Tests
Nuclear Magnetic Resonance, Biomolecular
Papua New Guinea
Plant Leaves chemistry
Plant Stems chemistry
T-Lymphocytes drug effects
Tuberculosis drug therapy
Antitubercular Agents chemistry
Antitubercular Agents isolation & purification
Antitubercular Agents pharmacology
Mycobacterium tuberculosis drug effects
Plants, Medicinal chemistry
Rhus chemistry
Squalene analogs & derivatives
Squalene chemistry
Squalene isolation & purification
Squalene pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 71
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 18710283
- Full Text :
- https://doi.org/10.1021/np800082e