Is beta-glucuronidase a clinical useful biomarker for an acute organophosphorus poisoning?

Authors :: Sabbe MB
Desruelles D
Lissens W
Source :: Human & experimental toxicology [Hum Exp Toxicol] 2008 May; Vol. 27 (5), pp. 431-3.
Publication Year :: 2008
Abstract: beta-glucuronidase is considered a sensitive biomarker for acute organophosphorus poisoning. In this well-documented study, multiple plasma samples over time were collected. A decrease in plasma concentration of beta-glucuronidase was surprisingly observed, even within normal range. These findings do not support the hypothesis that beta-glucuronidase is a useful biomarker for acute organophosphorus poisoning in humans.

Subjects :: Acetylcholinesterase blood
Atropine therapeutic use
Drug Therapy, Combination
Fluid Therapy
Humans
Male
Middle Aged
Obidoxime Chloride therapeutic use
Poisoning drug therapy
Poisoning enzymology
Propofol therapeutic use
Suicide, Attempted
Vasoconstrictor Agents therapeutic use
Biomarkers blood
Cholinesterase Inhibitors poisoning
Glucuronidase blood
Parathion poisoning
Poisoning blood

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