Back to Search
Start Over
Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2008 Oct; Vol. 122 (4), pp. 711-716. Date of Electronic Publication: 2008 Aug 20. - Publication Year :
- 2008
-
Abstract
- Background: It is currently discussed whether allergic sensitization may start in utero under the influence of the maternal immune system and environmental determinants.<br />Objective: To investigate the relationship between allergen-specific cord blood (CB) IgE levels, parental sensitization, CB cytokine production, and environmental influences.<br />Methods: As part of an ongoing multicenter birth cohort study, allergen-specific IgE antibodies against 20 common seasonal, perennial, and food allergens were measured in blood samples from 922 neonates, 922 mothers, and 835 fathers. Supernatants from stimulated CB cells were assessed for the production of IL-5, IFN-gamma, IL-10, and TNF-alpha.<br />Results: Allergen-specific IgE antibodies were detectable in 23.9% of newborns. Contamination with maternal serum was excluded by several means of analyses, including the absence of IgA antibodies. Clear correlation between maternal and fetal IgE was found only for hen's egg, cow's milk, and soybean allergen. Fetal IgE correlated negatively with the level of IFN-gamma production, but not with IL-5 and IL-10.<br />Conclusion: Allergen-specific IgE antibodies most probably of fetal origin are detectable in CB and correlate with a lowered CB IFN-gamma production.
- Subjects :
- Adult
Antibody Specificity immunology
Europe
Female
Fetal Blood immunology
Food Hypersensitivity immunology
Humans
Immunoglobulin E immunology
Infant, Newborn
Interferon-gamma immunology
Interleukin-5 blood
Interleukin-5 immunology
Male
Pregnancy
Prospective Studies
Rural Population
Allergens immunology
Fetal Blood metabolism
Food Hypersensitivity blood
Immunoglobulin E blood
Interferon-gamma biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 122
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Academic Journal
- Accession number :
- 18718651
- Full Text :
- https://doi.org/10.1016/j.jaci.2008.06.035