Back to Search Start Over

Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study.

Authors :
Pfefferle PI
Sel S
Ege MJ
Büchele G
Blümer N
Krauss-Etschmann S
Herzum I
Albers CE
Lauener RP
Roponen M
Hirvonen MR
Vuitton DA
Riedler J
Brunekreef B
Dalphin JC
Braun-Fahrländer C
Pekkanen J
von Mutius E
Renz H
Source :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2008 Oct; Vol. 122 (4), pp. 711-716. Date of Electronic Publication: 2008 Aug 20.
Publication Year :
2008

Abstract

Background: It is currently discussed whether allergic sensitization may start in utero under the influence of the maternal immune system and environmental determinants.<br />Objective: To investigate the relationship between allergen-specific cord blood (CB) IgE levels, parental sensitization, CB cytokine production, and environmental influences.<br />Methods: As part of an ongoing multicenter birth cohort study, allergen-specific IgE antibodies against 20 common seasonal, perennial, and food allergens were measured in blood samples from 922 neonates, 922 mothers, and 835 fathers. Supernatants from stimulated CB cells were assessed for the production of IL-5, IFN-gamma, IL-10, and TNF-alpha.<br />Results: Allergen-specific IgE antibodies were detectable in 23.9% of newborns. Contamination with maternal serum was excluded by several means of analyses, including the absence of IgA antibodies. Clear correlation between maternal and fetal IgE was found only for hen's egg, cow's milk, and soybean allergen. Fetal IgE correlated negatively with the level of IFN-gamma production, but not with IL-5 and IL-10.<br />Conclusion: Allergen-specific IgE antibodies most probably of fetal origin are detectable in CB and correlate with a lowered CB IFN-gamma production.

Details

Language :
English
ISSN :
1097-6825
Volume :
122
Issue :
4
Database :
MEDLINE
Journal :
The Journal of allergy and clinical immunology
Publication Type :
Academic Journal
Accession number :
18718651
Full Text :
https://doi.org/10.1016/j.jaci.2008.06.035