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Repeated treatments with albendazole enhance Th2 responses to Ascaris Lumbricoides, but not to aeroallergens, in children from rural communities in the Tropics.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2008 Oct 15; Vol. 198 (8), pp. 1237-42. - Publication Year :
- 2008
-
Abstract
- Geohelminth infections are associated with modulation of immunity to parasite antigens and aeroallergens. To investigate the possibility that this modulation is affected by anthelmintic treatment, we compared cytokine responses in children who were treated with repeated doses of albendazole over 1 year versus those in children who had were not treated. Whole-blood samples were cultured with Ascaris antigen and house dust mite and cockroach allergens, and levels of interleukin (IL)-5, IL-13, interferon-gamma, and IL-10 were measured. Anthelmintic treatment was associated with enhanced production of Th2 cytokines in response to parasite antigen but did not affect responses to aeroallergens. The data indicate that long-term treatment may be associated with increased Th2 antiparasite immunity.
- Subjects :
- Animals
Ascariasis drug therapy
Ascariasis epidemiology
Ascariasis parasitology
Ascaris lumbricoides immunology
Child
Cockroaches immunology
Cytokines biosynthesis
Cytokines immunology
Dust immunology
Ecuador epidemiology
Female
Humans
Hypersensitivity, Immediate epidemiology
Hypersensitivity, Immediate etiology
Hypersensitivity, Immediate immunology
Male
Mites immunology
Skin Tests
Treatment Outcome
Tropical Climate
Albendazole administration & dosage
Albendazole therapeutic use
Allergens immunology
Anthelmintics administration & dosage
Anthelmintics therapeutic use
Ascariasis immunology
Ascaris lumbricoides drug effects
Rural Population
Th2 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 198
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18729781
- Full Text :
- https://doi.org/10.1086/591945