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Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Sep 15; Vol. 18 (18), pp. 5087-90. Date of Electronic Publication: 2008 Aug 03. - Publication Year :
- 2008
-
Abstract
- A novel series of bacterial topoisomerase (3-aminoquinazolinediones) inhibitors are described. The side-chain SAR against Gram-positive and Gram-negative organisms as well as DNA gyrase activity is reported.
- Subjects :
- Combinatorial Chemistry Techniques
Fluoroquinolones chemical synthesis
Fluoroquinolones chemistry
Fluoroquinolones pharmacology
Microbial Sensitivity Tests
Molecular Structure
Structure-Activity Relationship
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Gram-Negative Bacteria drug effects
Gram-Negative Bacteria enzymology
Gram-Positive Bacteria drug effects
Gram-Positive Bacteria enzymology
Quinazolinones chemical synthesis
Quinazolinones chemistry
Quinazolinones pharmacology
Topoisomerase II Inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 18
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 18752951
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.07.117