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Equipotent concentrations of Botox and Dysport in the treatment of palmar hyperhidrosis.
- Source :
-
Acta dermato-venereologica [Acta Derm Venereol] 2008; Vol. 88 (5), pp. 458-61. - Publication Year :
- 2008
-
Abstract
- There are indications that the dilution of botulinum toxin affects dose-response. This must be considered when comparing different products. The aim of this study was to estimate a concentration of Dysport in physiological saline that is approximately equivalent to Botox 100 U/ml with respect to anhidrotic and muscular effect. Thirty-six patients with primary palmar hyperhidrosis were treated with multiple intradermal injections of 0.02 ml botulinum toxin. Botox(R) was injected in one hand and Dysport in the other in a random order. The concentrations of Dysport were 200 U/ml (n=18), 150 U/ml (n=11) and 100 U/ml (n=7). Muscular effect was measured as the reduction in compound muscle action potential in 3 muscles in the hand and anhidrotic effect was indicated by an iodine-starch test 4 weeks after treatment. Dysport at 200 U/ml was more potent than Botox at 100 U/ml with regard to both anhidrotic and muscular effect. The equipotent concentration of Dysport, compared with Botox 100 U/ml, was found to be in the range 100-150 U/ml.
- Subjects :
- Action Potentials drug effects
Adolescent
Adult
Dose-Response Relationship, Drug
Double-Blind Method
Female
Hand
Humans
Injections, Intradermal
Male
Middle Aged
Muscle Strength drug effects
Young Adult
Botulinum Toxins, Type A administration & dosage
Hyperhidrosis drug therapy
Neuromuscular Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0001-5555
- Volume :
- 88
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Acta dermato-venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 18779882
- Full Text :
- https://doi.org/10.2340/00015555-0490