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Association of CT60 polymorphism of the CTLA4 gene with Graves' disease in Taiwanese children.
- Source :
-
Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2008 Jul; Vol. 21 (7), pp. 665-72. - Publication Year :
- 2008
-
Abstract
- Background: The CTLA4 gene is involved in the activity of T cells.<br />Aim: To determine the association between Graves' disease (GD) susceptibility and CT60 polymorphism of the CTLA4 gene.<br />Patients: 189 children with GD and 620 healthy controls.<br />Methods: We determined the genotype with restriction fragment length polymorphism and compared results.<br />Results: Genotype G/G was significantly associated with GD (odds ratio [OR] = 1.71, 95% confidence interval [CI] 1.20-2.44, Pc = 0.006); however, allele A could reverse its effect. Allele G was significantly more frequent (OR = 1.61, 95% CI 1.18-2.19, Pc = 0.0049) but allele A (OR = 0.62, 95% CI 0.46-0.85, Pc = 0.0049) and phenotype A (OR = 0.58, 95% CI 0.41-0.83, Pc = 0.006) were less frequent in patients with GD than in controls.<br />Conclusion: The CT60 SNP was associated with susceptibility to GD. The G allele increased the risk of GD.
- Subjects :
- Adolescent
Adult
Age of Onset
Alleles
CTLA-4 Antigen
Child
Child, Preschool
DNA biosynthesis
DNA genetics
Female
Genotype
Humans
Infant
Male
Odds Ratio
Polymorphism, Restriction Fragment Length
Reverse Transcriptase Polymerase Chain Reaction
T-Lymphocytes metabolism
Taiwan epidemiology
Thyroid Function Tests
Thyrotropin blood
Thyroxine blood
Antigens, CD genetics
Graves Disease epidemiology
Graves Disease genetics
Polymorphism, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0334-018X
- Volume :
- 21
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of pediatric endocrinology & metabolism : JPEM
- Publication Type :
- Academic Journal
- Accession number :
- 18780601
- Full Text :
- https://doi.org/10.1515/jpem.2008.21.7.665