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Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2008 Sep 16; Vol. 105 (37), pp. 14157-62. Date of Electronic Publication: 2008 Sep 09. - Publication Year :
- 2008
-
Abstract
- New neurons are continuously generated in restricted regions of the adult mammalian brain. Although these adult-born neurons have been shown to receive synaptic inputs, little is known about their synaptic outputs. Using retrovirus-mediated birth-dating and labeling in combination with serial section electron microscopic reconstruction, we report that mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts with CA3 pyramidal cells within 2 weeks after their birth and reach morphologic maturity within 8 weeks in the adult hippocampus. Knockdown of Disrupted-in-Schizophrenia-1 (DISC1) in newborn granule cells leads to defects in axonal targeting and development of synaptic outputs in the adult brain. Together with previous reports of synaptic inputs, these results demonstrate that adult-born neurons are fully integrated into the existing neuronal circuitry. Our results also indicate a role for DISC1 in presynaptic development and may have implications for the etiology of schizophrenia and related mental disorders.
- Subjects :
- Animals
Animals, Newborn
Female
Mice
Mice, Inbred C57BL
Microscopy, Electron
Mossy Fibers, Hippocampal ultrastructure
Nerve Tissue Proteins genetics
Nerve Tissue Proteins metabolism
Neurons metabolism
RNA Interference
Synapses ultrastructure
Aging physiology
Mossy Fibers, Hippocampal growth & development
Neurons cytology
Synapses physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 105
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 18780780
- Full Text :
- https://doi.org/10.1073/pnas.0806658105