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Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain.

Authors :
Faulkner RL
Jang MH
Liu XB
Duan X
Sailor KA
Kim JY
Ge S
Jones EG
Ming GL
Song H
Cheng HJ
Source :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2008 Sep 16; Vol. 105 (37), pp. 14157-62. Date of Electronic Publication: 2008 Sep 09.
Publication Year :
2008

Abstract

New neurons are continuously generated in restricted regions of the adult mammalian brain. Although these adult-born neurons have been shown to receive synaptic inputs, little is known about their synaptic outputs. Using retrovirus-mediated birth-dating and labeling in combination with serial section electron microscopic reconstruction, we report that mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts with CA3 pyramidal cells within 2 weeks after their birth and reach morphologic maturity within 8 weeks in the adult hippocampus. Knockdown of Disrupted-in-Schizophrenia-1 (DISC1) in newborn granule cells leads to defects in axonal targeting and development of synaptic outputs in the adult brain. Together with previous reports of synaptic inputs, these results demonstrate that adult-born neurons are fully integrated into the existing neuronal circuitry. Our results also indicate a role for DISC1 in presynaptic development and may have implications for the etiology of schizophrenia and related mental disorders.

Details

Language :
English
ISSN :
1091-6490
Volume :
105
Issue :
37
Database :
MEDLINE
Journal :
Proceedings of the National Academy of Sciences of the United States of America
Publication Type :
Academic Journal
Accession number :
18780780
Full Text :
https://doi.org/10.1073/pnas.0806658105