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Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2008 Oct 15; Vol. 198 (8), pp. 1219-26. - Publication Year :
- 2008
-
Abstract
- Interleukin (IL)-1beta is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1beta polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1beta promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1beta levels were investigated in children with parasitemia (n= 566) from western Kenya. The IL-1beta promoter haplotype -31C/-511A (CA) was associated with increased risk of SMA (Hb level <6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P < .05) and reduced circulating IL-1beta levels (p <.05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA (OR, 0.52 [95% CI, 0.18-1.16]; p =.11) and elevated IL-1beta production ( p<.05). Compared with the non-SMA group, children with SMA had significantly lower IL-1beta levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1beta. The results presented demonstrate that variation in IL-1beta promoter conditions susceptibility to SMA and functional changes in circulating IL-1beta levels.
- Subjects :
- Animals
Child, Preschool
Female
Genotype
Haplotypes
Humans
Infant
Interleukin-1beta biosynthesis
Interleukin-1beta blood
Male
Parasitemia complications
Parasitemia genetics
Parasitemia immunology
Parasitemia parasitology
Plasmodium falciparum
Severity of Illness Index
Anemia genetics
Anemia immunology
Anemia physiopathology
Interleukin-1beta genetics
Malaria, Falciparum complications
Malaria, Falciparum genetics
Malaria, Falciparum immunology
Malaria, Falciparum parasitology
Polymorphism, Genetic
Promoter Regions, Genetic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 198
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18781863
- Full Text :
- https://doi.org/10.1086/592055