[Determination of ADAMTS13 antigen and activity levels in patients with acute myocardial infarction and acute ischemic stroke].

Authors :: Dong NZ
Liu F
Ji SD
Ruan CG
Source :: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2008 Mar; Vol. 29 (3), pp. 161-3.
Publication Year :: 2008
Abstract: Objective: To investigate the ADAMTS13 antigen levels and activity in patients with acute myocardial infarction (AMI) and acute ischemic stroke (AIS), and explore its significance in these diseases.<br />Methods: ADAMTS13 activity levels were detected by a new developed Frests-vWF73 kit, ADAMTS13 antigen levels by ELISA kit, and vWF multimers by electrophoresis.<br />Results: ADAMTS13 antigen in normal control, AMI and AIS was (878 +/- 198), (618 +/- 188) and (702 +/- 155) U/L, and ADAMTS13 activity was (81.7 +/- 13.9)%, (59.2 +/- 22.1 )% and (65.4 +/- 15.8)%, respectively, being significantly decreased in AMI and AIS patients.<br />Conclusion: ADMATS13 might involve in arterial infarction diseases.

Subjects :: ADAMTS13 Protein
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
von Willebrand Factor metabolism
ADAM Proteins blood
Brain Infarction blood
Myocardial Infarction blood

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