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Role of ischemia modified albumin to ST-segment resolution after mechanical reperfusion in patients with ST-segment elevation myocardial infarction.
- Source :
-
Atherosclerosis [Atherosclerosis] 2009 Apr; Vol. 203 (2), pp. 576-80. Date of Electronic Publication: 2008 Aug 06. - Publication Year :
- 2009
-
Abstract
- Objective: To investigate the possible association between admission ischemia modified albumin (IMA) levels and ST-segment resolution (STR) in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI).<br />Materials and Methods: We studied 117 patients with a first STEMI within 6h of the onset of pain. Admission serum IMA concentration was measured using a validated assay. The worst single electrocardiogram lead before and 90min after primary PCI was analyzed, and patients were divided into two groups according to the degree of STR: complete (> or =70%) or incomplete (<70%).<br />Results: Of the 117 patients, 70 (60%) had complete STR, and 47 (40%) incomplete STR. Serum IMA concentrations were significantly higher in patients that had incomplete STR (0.383+/-0.060A.U. vs. 0.297+/-0.056A.U., p<0.001). IMA levels >0.325A.U. demonstrated a sensitivity of 91.4% and a specificity of 45.7% for the diagnosis of incomplete STR; the area under the receiver operator characteristic curve was 0.849 (95% CI 0.77-0.92, p=0.0001). Moreover, IMA values were an independent predictor of incomplete STR even after adjustment for potential confounders (OR 2.34; 95% CI 1.20-4.64, p=0.01).<br />Conclusions: IMA may be a useful biomarker for the identification of incomplete STR in STEMI patients presenting to hospital within 6h of the onset of pain.
- Subjects :
- Aged
Angioplasty, Balloon, Coronary methods
Biomarkers metabolism
Electrocardiography methods
Female
Humans
Male
Middle Aged
ROC Curve
Sensitivity and Specificity
Time Factors
Treatment Outcome
Albumins metabolism
Ischemia metabolism
Myocardial Infarction diagnosis
Myocardial Infarction therapy
Reperfusion
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1484
- Volume :
- 203
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Atherosclerosis
- Publication Type :
- Academic Journal
- Accession number :
- 18789442
- Full Text :
- https://doi.org/10.1016/j.atherosclerosis.2008.07.033