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Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation.

Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation.

Authors :
Gu P
Su Y
Guo S
Teng L
Xu Y
Qi J
Gong H
Cai Y
Source :
Cancer investigation [Cancer Invest] 2008 Oct; Vol. 26 (8), pp. 822-9.
Publication Year :
2008

Abstract

COX-2 is involved in several pathological processes. The action of COX-2 on human ovarian cancer cell line (CAOV-3) and relative signal pathway has not been demonstrated. We explored the effects of COX-2 on the CAOV-3 viability and migration, moreover the proliferation of CAOV-3, and then ascertained the roles of PI3-k/Akt in these processes. The results showed that COX-2 increased the cells viability, migration and augment the number of CAOV-3. LY294002 could reduce COX-2 induce cells viability, migration and proliferation. These data indicate that COX-2 induce cells viability and migration, moreover promote the proliferation of CAOV-3 via PI3-k/Akt signal pathway.

Details

Language :
English
ISSN :
1532-4192
Volume :
26
Issue :
8
Database :
MEDLINE
Journal :
Cancer investigation
Publication Type :
Academic Journal
Accession number :
18798061
Full Text :
https://doi.org/10.1080/07357900801941860