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Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation.
Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation.
- Source :
-
Cancer investigation [Cancer Invest] 2008 Oct; Vol. 26 (8), pp. 822-9. - Publication Year :
- 2008
-
Abstract
- COX-2 is involved in several pathological processes. The action of COX-2 on human ovarian cancer cell line (CAOV-3) and relative signal pathway has not been demonstrated. We explored the effects of COX-2 on the CAOV-3 viability and migration, moreover the proliferation of CAOV-3, and then ascertained the roles of PI3-k/Akt in these processes. The results showed that COX-2 increased the cells viability, migration and augment the number of CAOV-3. LY294002 could reduce COX-2 induce cells viability, migration and proliferation. These data indicate that COX-2 induce cells viability and migration, moreover promote the proliferation of CAOV-3 via PI3-k/Akt signal pathway.
- Subjects :
- Cell Division
Cell Line, Tumor enzymology
Cell Movement
Cell Survival
Chromones pharmacology
Cyclooxygenase 2 genetics
DNA Replication
Female
Humans
Morpholines pharmacology
Ovarian Neoplasms enzymology
Phosphatidylinositol 3-Kinases physiology
Phosphoinositide-3 Kinase Inhibitors
Proto-Oncogene Proteins c-akt physiology
RNA, Messenger biosynthesis
RNA, Neoplasm biosynthesis
RNA, Small Interfering physiology
Recombinant Fusion Proteins physiology
Signal Transduction drug effects
Signal Transduction physiology
Transfection
Cyclooxygenase 2 physiology
Neoplasm Proteins physiology
Ovarian Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-4192
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cancer investigation
- Publication Type :
- Academic Journal
- Accession number :
- 18798061
- Full Text :
- https://doi.org/10.1080/07357900801941860