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Sympathetic activation in chronic renal failure.
- Source :
-
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2009 May; Vol. 20 (5), pp. 933-9. Date of Electronic Publication: 2008 Sep 17. - Publication Year :
- 2009
-
Abstract
- The potential involvement of sympathetic overactivity has been neglected in this population despite accumulating experimental and clinical evidence suggesting a crucial role of sympathetic activation for both progression of renal failure and the high rate of cardiovascular events in patients with chronic kidney disease. The contribution of sympathetic neural mechanisms to the occurrence of cardiac arrhythmias, the development of hypertension, and the progression of heart failure are well established; however, the exact mechanisms contributing to heightened sympathetic tone in patients with chronic kidney disease are unclear. This review analyses potential mechanisms underlying sympathetic activation in chronic kidney disease, the range of adverse consequences associated with this activation, and potential therapeutic implications resulting from this relationship.
- Subjects :
- Animals
Cardiovascular Diseases epidemiology
Cardiovascular Diseases mortality
Catecholamines blood
Clonidine therapeutic use
Debrisoquin therapeutic use
Disease Models, Animal
Efferent Pathways physiopathology
Humans
Hypertension drug therapy
Hypertension epidemiology
Hypertension mortality
Kidney innervation
Kidney Failure, Chronic epidemiology
Monoamine Oxidase deficiency
Monoamine Oxidase metabolism
Nerve Fibers physiology
Nitric Oxide physiology
Norepinephrine therapeutic use
Kidney Failure, Chronic complications
Kidney Failure, Chronic physiopathology
Sympathetic Nervous System physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1533-3450
- Volume :
- 20
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Nephrology : JASN
- Publication Type :
- Academic Journal
- Accession number :
- 18799718
- Full Text :
- https://doi.org/10.1681/ASN.2008040402