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Urinary neutrophil gelatinase associated lipocalin (NGAL), a marker of tubular damage, is increased in patients with chronic heart failure.
- Source :
-
European journal of heart failure [Eur J Heart Fail] 2008 Oct; Vol. 10 (10), pp. 997-1000. Date of Electronic Publication: 2008 Sep 18. - Publication Year :
- 2008
-
Abstract
- Renal impairment, as measured by reduced glomerular filtration rate (GFR) and increased urinary albumin excretion (UAE), is prevalent in patients with chronic heart failure (CHF) and is associated with reduced survival. The prevalence of structural tubular damage in CHF is unknown. We investigated 90 CHF patients and 20 age and sex matched healthy controls, and determined estimated GFR, UAE, N terminal-pro brain natriuretic peptide (NT-proBNP) and urinary neutrophil gelatinase associated lipocalin (NGAL) as a marker for tubular damage. CHF patients had significantly lower averaged estimated GFR (64+/-17 vs 90+/-12 mL/min/1.73 m(2), P<0.0001), but higher NT-proBNP and UAE levels (both P<0.0001). Median urinary NGAL levels were markedly increased in CHF patients compared to controls (175 (70-346) vs 37 (6-58) microg/gCr, P<0.0001). Both serum creatinine (r=0.26, P=0.006) and eGFR (r=-0.29, P=0.002) were significantly associated with urinary NGAL levels as were NT-proBNP and UAE but to a lesser extent. In conclusion, renal impairment in CHF patients is not only characterised by decreased eGFR and increased UAE, but also by the presence of tubular damage, as measured by increased urinary NGAL concentrations.
- Subjects :
- Albumins
Case-Control Studies
Chronic Disease
Creatine blood
Disease Progression
Female
Glomerular Filtration Rate
Heart Failure pathology
Heart Failure physiopathology
Humans
Kidney Diseases diagnosis
Lipocalin-2
Male
Middle Aged
Natriuretic Peptide, Brain
Peptide Fragments
Prevalence
Prognosis
Stroke Volume
Ventricular Function, Left
Acute-Phase Proteins urine
Heart Failure complications
Kidney Diseases pathology
Kidney Tubules pathology
Lipocalins urine
Proto-Oncogene Proteins urine
Subjects
Details
- Language :
- English
- ISSN :
- 1388-9842
- Volume :
- 10
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- European journal of heart failure
- Publication Type :
- Academic Journal
- Accession number :
- 18804416
- Full Text :
- https://doi.org/10.1016/j.ejheart.2008.07.001