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[Preclinical toxicological evaluation of Pentamang and Mangascan].

[Preclinical toxicological evaluation of Pentamang and Mangascan].

Authors :
Churin AA
Karpova GV
Fomina TI
Vetoshkina TV
Dubskaia TIu
Voronova OL
Filimonov VD
Belianin ML
Usov VIu
Source :
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2008 Jul-Aug; Vol. 71 (4), pp. 49-52.
Publication Year :
2008

Abstract

We have carried out a preclinical toxicological investigation (acute toxicity evaluation) of Mangascan (0.5 M solution of manganese(II) - EDTA complex) and Pentamang (0.5 M solution of manganese(II) - DTPA complex), a new paramagnetic contrast agents for MRI procedures. In 14 days after single intravenous introduction of Mangascan (10.0 ml/kg) or Pentamang (5.0 ml/kg) to rats, no any toxic influence of the studied agents was detected in the general condition, bone marrow, cardiovascular and central nervous systems, and liver and kidney functions of experimental animals. No pathological changes were observed in the functional activity and morphology of the internal organs and systems. The results showed that both Mangascan and Pentamang belong to the class of low toxicity substances.

Details

Language :
Russian
ISSN :
0869-2092
Volume :
71
Issue :
4
Database :
MEDLINE
Journal :
Eksperimental'naia i klinicheskaia farmakologiia
Publication Type :
Academic Journal
Accession number :
18819441