[Research advancement of bone marrow derived stem cell heterogeneity and its role in intestinal epithelial repair].

Authors :: Liu D
Su Y
Source :: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery [Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi] 2008 Sep; Vol. 22 (9), pp. 1130-4.
Publication Year :: 2008
Abstract: Objective: To summarize and review the heterogeneity of bone marrow derived stem cells (BMDSCs) and its formation mechanism and significance, and to analyze the possible roles and mechanisms in intestinal epithelial reconstruction.<br />Methods: The related literature about BMDSCs heterogeneity and its role in intestinal epithelial repair was reviewed and analyzed.<br />Results: The heterogeneity of BMDSCs provided better explanations for its multi-potency. The probable mechanisms of BMDSCs to repair intestinal epithelium included direct implantation into intestinal epithelium, fusion between BMDSCs and intestinal stem cells, and promotion of injury microcirculation reconstruction.<br />Conclusion: BMDSCs have a bright future in gastrointestinal injury caused by inflammatory bowl disease and regeneration.

Subjects :: Animals
Humans
Bone Marrow Cells cytology
Intestinal Mucosa physiology
Regeneration
Stem Cells physiology

Language :: Chinese
ISSN :: 1002-1892
Volume :: 22
Issue :: 9
Database :: MEDLINE
Journal :: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Publication Type :: Academic Journal
Accession number :: 18822745

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