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Evaluation of the pharmacokinetics of digoxin in healthy subjects receiving etoricoxib.
- Source :
-
British journal of clinical pharmacology [Br J Clin Pharmacol] 2008 Dec; Vol. 66 (6), pp. 811-7. Date of Electronic Publication: 2008 Sep 24. - Publication Year :
- 2008
-
Abstract
- Aims: Digoxin is a commonly prescribed cardiac glycoside with a narrow therapeutic index. The aim was to investigate whether the cyclooxygenase-2 selective nonsteroidal anti-inflammatory drug etoricoxib affects the steady-state pharmacokinetics of digoxin.<br />Methods: This was a double-blind, randomized, placebo-controlled, two-period cross-over study. In each period, 14 healthy volunteers ranging in age from 21 to 35 years received oral digoxin 0.25 mg daily and were randomized to either etoricoxib 120 mg or matching placebo tablets once daily for 10 days. Trough digoxin plasma concentrations were analysed by linear regression to examine digoxin accumulation over time.<br />Results: The geometric mean ratios (etoricoxib/placebo) for AUC(0-24h), C(max) and urinary excretion were 1.06 (90% confidence interval 0.97, 1.17), 1.33 (1.21, 1.46) and 1.10 (1.00, 1.20), respectively. The median (range) for digoxin T(max) (h) values with etoricoxib and placebo were 0.5 (0.5, 1.5) and 1.0 (0.5, 1.5), respectively. Steady-state digoxin plasma concentrations were achieved by day 7 in each treatment period. No serious adverse experiences were reported.<br />Conclusions: Although etoricoxib 120 mg did produce an approximately 33% increase in digoxin C(max), this increase does not appear to be clinically meaningful, as cardiotoxicity with digoxin has been associated with elevations in steady-state rather than peak concentrations. From these results, it appears that etoricoxib does not cause any changes in digoxin steady-state pharmacokinetics that would necessitate a dose adjustment.
- Subjects :
- Adult
Area Under Curve
Cardiac Glycosides administration & dosage
Cyclooxygenase Inhibitors administration & dosage
Digoxin administration & dosage
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug Interactions
Epidemiologic Methods
Etoricoxib
Female
Humans
Male
Metabolic Clearance Rate
Pyridines administration & dosage
Sulfones administration & dosage
Young Adult
Cardiac Glycosides pharmacokinetics
Cyclooxygenase Inhibitors pharmacokinetics
Digoxin pharmacokinetics
Pyridines pharmacokinetics
Sulfones pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2125
- Volume :
- 66
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- British journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 18823299
- Full Text :
- https://doi.org/10.1111/j.1365-2125.2008.03285.x