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CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain.

Authors :
Schweitzer B
Philippsen P
Source :
Yeast (Chichester, England) [Yeast] 1991 Apr; Vol. 7 (3), pp. 265-73.
Publication Year :
1991

Abstract

The cell division cycle gene CDC15 is essential for the late nuclear division in the yeast Saccharomyces cerevisiae. The amino acid sequence of the 974 amino acids/110 kDa CDC15 gene product, as deduced from the nucleotide sequence, includes an aminoterminal protein kinase domain which contains a primary sequence mosaic showing patterns specific for protein serine/threonine kinases besides those for protein tyrosine kinases. Many protein kinases non-essential for growth are known. CDC15 represents an essential protein kinase like CDC7 and CDC28. A carboxyterminal deletion of 32 amino acids renders the protein inactive.

Details

Language :
English
ISSN :
0749-503X
Volume :
7
Issue :
3
Database :
MEDLINE
Journal :
Yeast (Chichester, England)
Publication Type :
Academic Journal
Accession number :
1882551
Full Text :
https://doi.org/10.1002/yea.320070308