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CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain.
- Source :
-
Yeast (Chichester, England) [Yeast] 1991 Apr; Vol. 7 (3), pp. 265-73. - Publication Year :
- 1991
-
Abstract
- The cell division cycle gene CDC15 is essential for the late nuclear division in the yeast Saccharomyces cerevisiae. The amino acid sequence of the 974 amino acids/110 kDa CDC15 gene product, as deduced from the nucleotide sequence, includes an aminoterminal protein kinase domain which contains a primary sequence mosaic showing patterns specific for protein serine/threonine kinases besides those for protein tyrosine kinases. Many protein kinases non-essential for growth are known. CDC15 represents an essential protein kinase like CDC7 and CDC28. A carboxyterminal deletion of 32 amino acids renders the protein inactive.
- Subjects :
- Amino Acid Sequence
Base Sequence
Molecular Sequence Data
Mutagenesis
Open Reading Frames
Plasmids
Protein Kinases chemistry
Restriction Mapping
Saccharomyces cerevisiae cytology
Saccharomyces cerevisiae enzymology
TATA Box
Cell Cycle genetics
DNA, Fungal chemistry
Protein Kinases genetics
Saccharomyces cerevisiae genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0749-503X
- Volume :
- 7
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Yeast (Chichester, England)
- Publication Type :
- Academic Journal
- Accession number :
- 1882551
- Full Text :
- https://doi.org/10.1002/yea.320070308