[Study on the relationship between GSTM1, GSTT1 gene polymorphisms and arsenic methylation level].

Objective: To investigate the relationship between genetic polymorphisms of GSTT1, GSTM1 and arsenic methylation level.
Methods: 247 residents in an industrial arsenic polluted village were randomly selected as subjects. The genetic polymorphisms of GSTM1 and GSTT1 were detected by multiple PCR method. Urinary inorganic arsenic (iAs), monomethylarsenic acid (MMA) and dimethylarsenic acid (DMA) concentrations were determined by ion chromatogram combined with HG-AFS.
Results: No significant differences in the relative proportion of urinary iAs, MMA and DMA were observed between the individuals with GSTT1 positive genotype and the individuals with GSTT1 null genotype. No significant differences in the relative proportion of urinary iAs, MMA and DMA were observed between the individuals with GSTM1 positive genotype and the individuals with GSTM1 null genotype. And no significant differences in the relative proportion of urinary iAs, MMA and DMA was observed among the individuals with different GSTM1 and GSTT1 associated genotype.
Conclusion: The polymorphisms of GSTT1 and GSTM1 were not associated with arsenic metabolism level in the studied population.