Effect of a successful intensive lifestyle program on insulin sensitivity and glucose tolerance in obese youth.

Objective: To evaluate the impact on glucose metabolism of a lifestyle program (the Yale Bright Bodies Program) for obese children.
Research Design and Methods: Thirteen Bright Bodies and ten clinic-care control subjects who were part of a large randomized clinical trial had 75-g oral glucose tolerance tests at the beginning and end of the 12-month study.
Results: Bright Bodies subjects had significantly greater decreases in weight, BMI, and body fat than clinic-care subjects, and the Bright Body subjects' changes in body composition were accompanied by marked improvements in insulin sensitivity (P = 0.009) and glucose tolerance (P = 0.04).
Conclusions: An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.