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Molecular expression of Gastrokine 1 in normal mucosa and in Helicobacter pylori-related preneoplastic and neoplastic gastric lesions.
- Source :
-
Cancer biology & therapy [Cancer Biol Ther] 2008 Dec; Vol. 7 (12), pp. 1890-5. Date of Electronic Publication: 2008 Dec 07. - Publication Year :
- 2008
-
Abstract
- We have analyzed the expression of Gastrokine 1 (GKN1), one of the most abundant protein of gastric mucosa, in Helicobacter pylori-related preneoplastic and neoplastic gastric lesions. The GKN1 expression was downregulated in 36 H. pylori-positive patients with respect to 29 H. pylori-negative subjects as evaluated by Western blot, reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry, showing a progressive decrease from chronic gastritis to atrophy and intestinal metaplasia. Interestingly, in gastric cancer (GC) patients, GKN1 was undetectable in tissue tumoral areas but was instead expressed in the corresponding tissue non-tumoral areas. In conclusion our data suggests that GKN1 expression is related to the inflammatory damage of gastric mucosa and could be the related to the gastric cellular phenotype.
- Subjects :
- Adult
Atrophy
DNA Primers
Dyspepsia genetics
Dyspepsia pathology
Female
Helicobacter pylori
Humans
Male
Metaplasia genetics
Metaplasia pathology
Middle Aged
Precancerous Conditions pathology
Reverse Transcriptase Polymerase Chain Reaction
Stomach Neoplasms pathology
Young Adult
Gastric Mucosa pathology
Gastric Mucosa physiology
Helicobacter Infections complications
Peptide Hormones genetics
Precancerous Conditions genetics
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1555-8576
- Volume :
- 7
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Cancer biology & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 18927498
- Full Text :
- https://doi.org/10.4161/cbt.7.12.6936