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One year follow-up of children and adolescents with chronic immune thrombocytopenic purpura (ITP) treated with rituximab.
- Source :
-
Pediatric blood & cancer [Pediatr Blood Cancer] 2009 Feb; Vol. 52 (2), pp. 259-62. - Publication Year :
- 2009
-
Abstract
- Background: We previously showed in a prospective study that rituximab appears to be effective in some children and adolescents with severe chronic immune thrombocytopenia. Eleven of 36 patients achieved and maintained platelet counts over 50,000/mm(3) within the first 12 weeks. These patients were followed for the next year.<br />Methods: Platelet counts were monitored monthly and all subsequent bleeding manifestations and need for further treatment was noted.<br />Results: Eight of the 11 initial responders maintained a platelet count over 150,000/mm(3) without further treatment intervention. Three patients had a late relapse. One initial non-responder achieved a remission after 16 weeks, and two additional patients maintained platelet counts around 50,000/mm(3) without the need for further intervention.<br />Conclusions: Rituximab resulted in sustained efficacy with platelet counts of 50,000/mm(3) or higher in 11 of 36 patients (31%).<br /> ((c) 2008 Wiley-Liss, Inc.)
- Subjects :
- Adolescent
Antibodies, Monoclonal, Murine-Derived
Child
Child, Preschool
Chronic Disease
Female
Follow-Up Studies
Hemorrhage
Humans
Infant
Male
Platelet Count
Recurrence
Remission Induction
Rituximab
Antibodies, Monoclonal administration & dosage
Purpura, Thrombocytopenic, Idiopathic drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1545-5017
- Volume :
- 52
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pediatric blood & cancer
- Publication Type :
- Academic Journal
- Accession number :
- 18937333
- Full Text :
- https://doi.org/10.1002/pbc.21757