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The role of different glutamate receptors in the mediation of glutamate-evoked excitation of red nucleus neurons after simulated microgravity in rat.
- Source :
-
Neuroscience letters [Neurosci Lett] 2008 Dec 31; Vol. 448 (3), pp. 255-9. Date of Electronic Publication: 2008 Oct 17. - Publication Year :
- 2008
-
Abstract
- The present study investigates changes in red nucleus (RN) neuronal activity and the role of glutamate receptors (GluRs) after simulated microgravity (tail-suspension) in the rat using single-unit recording and microinjection. The results showed that tail-suspension for 3, 7, and 14 days could induce a significant decrease in spontaneous firing rate of RN neurons in a time-dependent manner. Unilateral microinjection of glutamate into the RN significantly increased the firing rate of RN neurons, but the increased firing rate was significantly reduced following tail-suspension time. Microinjection of the NMDA receptor antagonist MK-801 or the non-NMDA receptor antagonist DNQX into the RN blocked this excitatory effect induced by glutamate. However, microinjection of the metabotropic glutamate receptor (mGluR) antagonist (+/-)-MCPG into the RN had no effect. These results suggest that simulated microgravity can reduce excitability of RN neurons following a functional impairment of glutamate receptors. NMDA and non-NMDA receptors, but not mGluRs, are involved in the mediation of glutamate-evoked excitation of RN neurons. The decrease in excitability of RN neurons may be involved in simulated microgravity-induced muscle atrophy.
- Subjects :
- Animals
Dizocilpine Maleate pharmacology
Electrophysiology
Excitatory Amino Acid Agonists pharmacology
Excitatory Amino Acid Antagonists pharmacology
Female
Glycine analogs & derivatives
Glycine pharmacology
Hindlimb Suspension
Microinjections
Quinoxalines pharmacology
Rats
Rats, Sprague-Dawley
Receptors, Glutamate drug effects
Red Nucleus cytology
Stimulation, Chemical
Glutamic Acid pharmacology
Neurons drug effects
Receptors, Glutamate physiology
Red Nucleus drug effects
Weightlessness Simulation
Subjects
Details
- Language :
- English
- ISSN :
- 0304-3940
- Volume :
- 448
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 18950683
- Full Text :
- https://doi.org/10.1016/j.neulet.2008.10.044