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COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men.
- Source :
-
Carcinogenesis [Carcinogenesis] 2008 Dec; Vol. 29 (12), pp. 2347-50. Date of Electronic Publication: 2008 Oct 28. - Publication Year :
- 2008
-
Abstract
- Cyclooxygenase-2 (COX-2) converts arachidonic acid to prostaglandins, which are important mediators of cell proliferation and inflammation. Evidence indicates that COX-2 plays a role in carcinogenesis and that it is over-expressed in prostate tumours. We investigated the role of COX-2 variants in prostate cancer in a case-control study of South African Coloured men, consisting of 151 cases and 134 controls. The genotype frequencies of four single-nucleotide polymorphisms (SNPs) in the COX-2 promoter were initially determined in 50 control subjects. One SNP, rs20417 (-899G>C), was monomorphic and excluded from further investigation. Three SNPs, rs3918304 (-1285A>G), rs20415 (-1265C>T) and rs5270 (-297C>G), were genotyped in all the case patients and control subjects. The -1285 G-allele and -1265 T-allele were associated with increased risk of prostate cancer [odds ratio (OR) = 3.53; confidence interval (CI) = 2.14-5.90; P < 0.0001 and OR = 3.01; CI = 1.82-5.02; P < 0.0001] after adjusting for age. Haplotype GTC conferred increased risk of prostate cancer in South African Coloured men (OR = 3.54 versus ACC; CI = 2.12-5.92; P < 0.0001). These findings in conjunction with findings in other populations of African descent might suggest a common causal variant for prostate cancer in COX-2, or a variant in a nearby gene.
- Subjects :
- Aged
Aged, 80 and over
Black People genetics
Case-Control Studies
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Middle Aged
Risk Factors
South Africa
Cyclooxygenase 2 genetics
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Promoter Regions, Genetic genetics
Prostatic Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2180
- Volume :
- 29
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Carcinogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 18974063
- Full Text :
- https://doi.org/10.1093/carcin/bgn245