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A visual analytics system for breast tumor evaluation.

Authors :: Petushi S
Marker J
Zhang J
Zhu W
Breen D
Chen C
Lin X
Garcia FU
Source :: Analytical and quantitative cytology and histology [Anal Quant Cytol Histol] 2008 Oct; Vol. 30 (5), pp. 279-90.
Publication Year :: 2008
Abstract: Objective: To develop a system for the interactive exploration and examination of histologically derived data that is associated with breast tumors and may be used to evaluate the histologic grade of the tumor.<br />Study Design: The system integrates pathologist-generated prognostic data with 2-dimensional (2-D) image analysis data, 2-D digital tissue cross-sections and annotations, 3-dimensional (3-D) tumor reconstructions and volumetric analysis, 3D spatial tumor display and recorded prognostic information from available cases in the Drexel University College of Medicine tumor databank. The system consists of 3 components: (1) a user interface for applying 2-D image processing, segmentation and annotation to a digitized histology slide, (2) a distance field interpolation method for contour-based 3D reconstruction of breast tumors and volumetric model analysis routines and (3) a Web-based database management interface for interactive data browsing and searching and multimodality visualization.<br />Results: The system has been implemented and deployed with data from 36 breast cancer cases, 7 of which have been reconstructed in 3-D.<br />Conclusion: Interactive visual analytics technology may be used to create an effective breast tumor evaluation system.