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A syndrome resembling Bartter's syndrome in sarcoidosis.
- Source :
-
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association [Nephrol Dial Transplant] 2009 Feb; Vol. 24 (2), pp. 667-9. Date of Electronic Publication: 2008 Nov 05. - Publication Year :
- 2009
-
Abstract
- Acquired Bartter-like syndrome, albeit rare, has not been reported to be associated with sarcoidosis. We describe the case of a 32-year-old male patient who presented with progressive muscular weakness of both lower extremities. Profound hypokalaemia associated with renal (K(+)) wasting, bilateral nephrocalcinosis and high plasma renin activity resembled Bartter's syndrome (BS). Both mediastinal lymph node and renal biopsy demonstrated sarcoidosis with non-caseating granuloma. Genetic testing responsible for hereditary BS or Gitelman's syndrome (GS) was negative. Hypokalaemia was well controlled with the administration of spironolactone with oral steroids and KCl. Early recognition and prompt treatment of sarcoidosis-associated Bartter-like syndrome avoids unnecessary complications.
- Subjects :
- Adult
Bartter Syndrome classification
Bartter Syndrome etiology
Diagnosis, Differential
Humans
Hypokalemia complications
Hypokalemia drug therapy
Kidney Diseases pathology
Male
Nephrocalcinosis complications
Renin blood
Sarcoidosis pathology
Bartter Syndrome complications
Bartter Syndrome diagnosis
Kidney Diseases complications
Sarcoidosis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2385
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
- Publication Type :
- Academic Journal
- Accession number :
- 18987258
- Full Text :
- https://doi.org/10.1093/ndt/gfn600