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Fat metabolism links germline stem cells and longevity in C. elegans.
- Source :
-
Science (New York, N.Y.) [Science] 2008 Nov 07; Vol. 322 (5903), pp. 957-60. - Publication Year :
- 2008
-
Abstract
- Fat metabolism, reproduction, and aging are intertwined regulatory axes; however, the mechanism by which they are coupled remains poorly understood. We found that germline stem cells (GSCs) actively modulate lipid hydrolysis in Caenorhabditis elegans, which in turn regulates longevity. GSC arrest promotes systemic lipolysis via induction of a specific fat lipase. Subsequently, fat mobilization is promoted and life span is prolonged. Constitutive expression of this lipase in fat storage tissue generates lean and long-lived animals. This lipase is a key factor in the lipid hydrolysis and increased longevity that are induced by decreased insulin signaling. These results suggest a link between C. elegans fat metabolism and longevity.
- Subjects :
- Aging
Animals
Caenorhabditis elegans genetics
Caenorhabditis elegans metabolism
Caenorhabditis elegans Proteins genetics
Caenorhabditis elegans Proteins metabolism
Cell Differentiation
Cell Proliferation
Forkhead Transcription Factors
Genes, Helminth
Germ Cells cytology
Hydrolysis
Intestinal Mucosa metabolism
Intestines cytology
Intracellular Signaling Peptides and Proteins metabolism
Lipase genetics
Models, Animal
Receptor, Insulin metabolism
Reproduction
Signal Transduction
Stem Cells cytology
Temperature
Transcription Factors metabolism
Caenorhabditis elegans physiology
Germ Cells metabolism
Lipase metabolism
Lipid Metabolism
Longevity
Stem Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 322
- Issue :
- 5903
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 18988854
- Full Text :
- https://doi.org/10.1126/science.1162011