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[Prophylactic effect of inductive intravesical instillation of Bacillus Calmette-Guerin on postoperative recurrence of bladder cancer].
- Source :
-
Ai zheng = Aizheng = Chinese journal of cancer [Ai Zheng] 2008 Nov; Vol. 27 (11), pp. 1208-11. - Publication Year :
- 2008
-
Abstract
- Background & Objective: Intravesical instillation is an important adjuvant therapy on preventing postoperative recurrence of superficial bladder transitional cell carcinoma, but the recurrence rate is still high. This study was to evaluate the prophylactic effect of intravesical instillation of hydroxycamptothecin (HYD) plus bacillus Calmette-Guerin (BCG) on postoperative recurrence of bladder transitional cell cancer.<br />Methods: A total of 45 bladder cancer patients who underwent TURBT or partial cystectomy were divided into two groups: 24 patients in combination group received single intravesical instillation of HYD in Week 1 after operation and regular intravesical instillation of BCG since Week 2; 21 patients in BCG group received regular intravesical instillation of BCG since Week 1 after operation. All the patients were followed up for 24 months.<br />Results: Three patients had recurrence at 2, 10, and 12 months after operation individually in BCG group; no recurrence developed in combination group. The recurrence rate was significantly higher in BCG group than in combination group (14.28% vs. 0, P<0.05). No serious adverse events and complication developed in both groups.<br />Conclusion: Early use of single intravesical instillation of HYD plus subsequent regular intravesical instillation of BCG is markedly effective for preventing postoperative recurrence of bladder transitional cell cancer, with few adverse events.
- Subjects :
- Adjuvants, Immunologic administration & dosage
Adjuvants, Immunologic adverse effects
Adjuvants, Immunologic therapeutic use
Administration, Intravesical
Adult
Aged
Aged, 80 and over
Antineoplastic Agents, Phytogenic administration & dosage
Antineoplastic Agents, Phytogenic adverse effects
Antineoplastic Agents, Phytogenic therapeutic use
BCG Vaccine administration & dosage
BCG Vaccine adverse effects
Camptothecin administration & dosage
Camptothecin adverse effects
Camptothecin therapeutic use
Carcinoma, Transitional Cell surgery
Cystectomy
Female
Fever chemically induced
Follow-Up Studies
Humans
Male
Middle Aged
Urinary Bladder Neoplasms surgery
BCG Vaccine therapeutic use
Camptothecin analogs & derivatives
Carcinoma, Transitional Cell drug therapy
Neoplasm Recurrence, Local prevention & control
Urinary Bladder Neoplasms drug therapy
Subjects
Details
- Language :
- Chinese
- Volume :
- 27
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Ai zheng = Aizheng = Chinese journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 19000455