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Adaptation of firing rate and spike-timing precision in the avian cochlear nucleus.
- Source :
-
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2008 Nov 12; Vol. 28 (46), pp. 11906-15. - Publication Year :
- 2008
-
Abstract
- Adaptation is commonly defined as a decrease in response to a constant stimulus. In the auditory system such adaptation is seen at multiple levels. However, the first-order central neurons of the interaural time difference detection circuit encode information in the timing of spikes rather than the overall firing rate. We investigated adaptation during in vitro whole-cell recordings from chick nucleus magnocellularis neurons. Injection of noisy, depolarizing current caused an increase in firing rate and a decrease in spike time precision that developed over approximately 20 s. This adaptation depends on sustained depolarization, is independent of firing, and is eliminated by alpha-dendrotoxin (0.1 microM), implicating slow inactivation of low-threshold voltage-activated K+ channels as its mechanism. This process may alter both firing rate and spike-timing precision of phase-locked inputs to coincidence detector neurons in nucleus laminaris and thereby adjust the precision of sound localization.
- Subjects :
- Acoustic Stimulation
Animals
Auditory Perception physiology
Birds anatomy & histology
Chick Embryo
Organ Culture Techniques
Patch-Clamp Techniques
Potassium Channels physiology
Reaction Time physiology
Synaptic Transmission physiology
Time Factors
Action Potentials physiology
Adaptation, Physiological physiology
Birds physiology
Cochlear Nucleus physiology
Neurons physiology
Sound Localization physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2401
- Volume :
- 28
- Issue :
- 46
- Database :
- MEDLINE
- Journal :
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 19005056
- Full Text :
- https://doi.org/10.1523/JNEUROSCI.3827-08.2008