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Impact of laparoscopic Roux-en-Y gastric bypass on metabolic syndrome, inflammation, and insulin resistance in super versus morbidly obese women.
- Source :
-
Obesity surgery [Obes Surg] 2009 May; Vol. 19 (5), pp. 577-82. Date of Electronic Publication: 2008 Nov 19. - Publication Year :
- 2009
-
Abstract
- Background: Although Roux-en-Y gastric bypass (RYGBP) is one of the preferred bariatric procedures in obese individuals, the efficacy of this procedure in the setting of super-obesity [body mass index (BMI) >/=50] is unclear. The aim of this study was to compare the efficacy of laparoscopic (L) RYGBP to reverse metabolic syndrome, inflammation, and insulin resistance in super-obese women compared to morbidly obese women.<br />Methods: Seventy-three consecutive women were enrolled in this prospective study. Anthropometric, metabolic, and inflammatory biological parameters were assessed in 18 super-obese and 55 morbidly obese women before LRYGBP and 1 year after surgery. Metabolic syndrome was diagnosed according to the International Diabetes Federation definition.<br />Results: Before surgery, super-obese women had a higher BMI, fat mass, blood insulin, and HOMA1-IR than morbidly obese women. Both groups had similar serum levels of C-reactive protein and orosomucoid. The incidence of metabolic syndrome, type 2 diabetes, and increased liver enzymes was comparable in the two groups. One year after LRYGBP, metabolic syndrome, type 2 diabetes, metabolic and inflammatory biological parameters were improved in the whole study population. A similar degree of improvement was observed in super-obese and morbidly obese women, although BMI and fat mass were persistently higher in super-obese patients.<br />Conclusions: One year after surgery, LRYGBP was equally effective at reversing metabolic syndrome, inflammation, and insulin resistance in morbidly obese and super-obese women.
- Subjects :
- Adult
Body Mass Index
C-Reactive Protein metabolism
Female
Follow-Up Studies
Humans
Incidence
Inflammation blood
Inflammation epidemiology
Metabolic Syndrome blood
Metabolic Syndrome epidemiology
Middle Aged
Obesity, Morbid complications
Orosomucoid metabolism
Treatment Outcome
Gastric Bypass
Inflammation prevention & control
Laparoscopy
Metabolic Syndrome prevention & control
Obesity, Morbid metabolism
Obesity, Morbid surgery
Subjects
Details
- Language :
- English
- ISSN :
- 0960-8923
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Obesity surgery
- Publication Type :
- Academic Journal
- Accession number :
- 19018603
- Full Text :
- https://doi.org/10.1007/s11695-008-9764-8