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Correlates of PLMs variability over multiple nights and impact upon RLS diagnosis.
- Source :
-
Sleep medicine [Sleep Med] 2009 Jun; Vol. 10 (6), pp. 668-71. Date of Electronic Publication: 2008 Nov 20. - Publication Year :
- 2009
-
Abstract
- Objective: Night-to-night variability of periodic leg movements (PLMs) in restless legs syndrome (RLS) was examined to define the range of intra-subject values, impact upon diagnosing RLS, and clinical correlates.<br />Methods: Twenty RLS patients were monitored for 10-15 nights using a validated, tri-axial accelerometer worn on the ankle.<br />Results: The mean difference in PLMs index (PLMI) between the lowest and highest night was 25.1/h (range: 3.9-73.8). Inter-subject differences accounted for nearly five times the variance in PLMI relative to between nights within an individual. Based on a single night of recording, PLMI criterion thresholds of 5, 10, and 15/h were exceeded on approximately 70.1%, 51.9% and 34.1% of individual nights among these patients. Based on five randomly sampled nights of recordings, the likelihood that such thresholds were met on at least a single night increased to 91.2%, 80.8% and 62.7%, respectively. Women exhibited greater variability.<br />Conclusions: Variability in PLMs within RLS subjects was substantial, yet individuals' characteristic PLM level represented a quantitative trait. Variability was unrelated to age or scores on scales of RLS severity, sleepiness, functional status, and mood. A larger number of recording nights increased the likelihood that any criterion was reached.
Details
- Language :
- English
- ISSN :
- 1878-5506
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Sleep medicine
- Publication Type :
- Academic Journal
- Accession number :
- 19022704
- Full Text :
- https://doi.org/10.1016/j.sleep.2008.06.009