Back to Search
Start Over
Plasma and placental nitric oxide levels in women with and without pre-eclampsia living at different altitudes.
- Source :
-
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2009 Feb; Vol. 104 (2), pp. 140-2. Date of Electronic Publication: 2008 Nov 22. - Publication Year :
- 2009
-
Abstract
- Objective: To investigate the nitric oxide (NO) levels in the plasma and the placentas of pregnant women with pre-eclampsia and women without pre-eclampsia, and to determine the effect of high or low altitude of residence.<br />Methods: NO was determined by chemoluminescence and group comparisons were performed.<br />Results: Women with pre-eclampsia (n=63) had higher plasma NO levels (38.6+/-17.44 vs 30.6+/-12.44 micromol/L, P=0.004) and higher placental NO levels (38.5+/-17.0 vs 24.3+/-7.16 ng/mg protein, P<0.05) compared with women without pre-eclampsia. A similar trend was found when comparisons were made according to altitude of residence. NO levels were significantly higher in the plasma of pre-eclamptic women living at sea level (41.11+/-18.78 vs 28.96+/-9.57 micromol/L, P=0.003), and in the placentas of women living at high altitude (39.51+/-16.98 vs 21.91+/-6.64 ng/mg protein, P<0.0001).<br />Conclusion: Women with pre-eclampsia had higher plasma and placental NO levels and the differences were associated with altitude of residence.
Details
- Language :
- English
- ISSN :
- 0020-7292
- Volume :
- 104
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 19027900
- Full Text :
- https://doi.org/10.1016/j.ijgo.2008.09.010