Back to Search
Start Over
Acute hematologic effects of interferon alpha, interferon gamma, tumor necrosis factor alpha and interleukin 2.
- Source :
-
Annals of hematology [Ann Hematol] 1991 Feb; Vol. 62 (1), pp. 25-31. - Publication Year :
- 1991
-
Abstract
- This study was designed to investigate acute effects of various doses of the cytokines IFN-alpha, IFN-gamma, Interleukin 2 and tumor necrosis factor alpha on white blood cell differential counts. Before initiation of phase II trials, a dose-determination phase was performed, where three different dose levels of each cytokine were applied as a single dose. White blood cell differential counts were assessed immediately before and 2, 12, 24, 48 and 168 h after injection. Patients enrolled suffered from metastatic cancer or chronic active hepatitis. In addition, IFN-alpha was administered to five healthy volunteers. Results indicate that cytokines cause rapid and transient changes in the numbers of leukocyte subsets. Hematologic changes were cell-type- and cytokine-specific: transient lymphopenia was observed after administration of all four cytokines, reaching a nadir 12 to 24 h after subcutaneous injection. Administration of TNF-alpha and IFN-gamma also caused transient monocytopenia. Neutrophilia developed after administration of Interleukin 2, IFN-alpha and TNF-alpha. We conclude that cytokines play a key role in the regulation of peripheral blood cell traffic by their capacity to influence homing patterns of peripheral blood leukocytes.
- Subjects :
- Female
Granulocytes pathology
Hepatitis, Chronic pathology
Hepatitis, Chronic therapy
Humans
Interferon Type I therapeutic use
Interferon-gamma therapeutic use
Interleukin-2 therapeutic use
Kinetics
Leukocyte Count
Lymphocytes pathology
Male
Monocytes pathology
Neoplasms pathology
Neoplasms therapy
Recombinant Proteins adverse effects
Recombinant Proteins therapeutic use
Tumor Necrosis Factor-alpha therapeutic use
Interferon Type I adverse effects
Interferon-gamma adverse effects
Interleukin-2 adverse effects
Leukocytes pathology
Tumor Necrosis Factor-alpha adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0939-5555
- Volume :
- 62
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 1903309
- Full Text :
- https://doi.org/10.1007/BF01714980