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Chemopreventive effects of anastrozole in a premenopausal breast cancer model.
- Source :
-
Anticancer research [Anticancer Res] 2008 Sep-Oct; Vol. 28 (5A), pp. 2819-23. - Publication Year :
- 2008
-
Abstract
- Background: Monotherapy with aromatase inhibitors has no established role in premenopausal breast cancer in women and is an area of future exploration.<br />Materials and Methods: In this study, chemopreventive effects of anastrozole in the model of N-methyl-N-nitrosourea-induced premenopausal mammary carcinogenesis in female rats were evaluated. Anastrozole was dietarily administered at two concentrations: 0.05 mg/kg (ANA 0.05) and 0.5 mg/kg (ANA 0.5). Basic parameters of experimental carcinogenesis and side-effects on selected organs after anastrozole treatment in animals were assessed.<br />Results: In the ANA 0.5 group, anastrozole suppressed tumor incidence by 40% (p<0.05) and tumor frequency by 57% (p<0.01), as well as lengthening the latency period by 10 days (p=0.084) compared to control animals. Adverse effects of anastrozole on the genital system (uterus and vagina) and lipid and bone metabolism in rats were not found. Anastrozole did not alter serum concentrations of estradiol, testosterone or dehydroepiandrosterone in animals. An increase in the body weight gain of rats in the ANA 0.5 group compared with the controls (p<0.01) was observed.<br />Conclusion: This study is the first about the antineoplastic effects of anastrozole in a model of premenopausal mammary carcinogenesis in female rats.
- Subjects :
- Anastrozole
Animals
Antineoplastic Agents, Hormonal toxicity
Dehydroepiandrosterone blood
Diet
Dose-Response Relationship, Drug
Estradiol blood
Male
Mammary Neoplasms, Experimental blood
Mammary Neoplasms, Experimental chemically induced
Methylnitrosourea
Nitriles toxicity
Rats
Rats, Sprague-Dawley
Testosterone blood
Triazoles toxicity
Antineoplastic Agents, Hormonal administration & dosage
Mammary Neoplasms, Experimental prevention & control
Nitriles administration & dosage
Triazoles administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 28
- Issue :
- 5A
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 19035316