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Polarity and differential inheritance--universal attributes of life?

Authors :
Macara IG
Mili S
Source :
Cell [Cell] 2008 Nov 28; Vol. 135 (5), pp. 801-12.
Publication Year :
2008

Abstract

When and why did cell polarization arise? Recent work in bacteria and yeast suggests that polarization may have evolved to restrict senescence to one daughter during division by enabling the differential segregation of damaged material. In more complex organisms, polarity functions have diversified to permit the differential inheritance of centrosomes, RNAs, proteins, and membranes, which is essential for the generation of diverse cell types from stem cells and for morphogenesis.

Details

Language :
English
ISSN :
1097-4172
Volume :
135
Issue :
5
Database :
MEDLINE
Journal :
Cell
Publication Type :
Academic Journal
Accession number :
19041746
Full Text :
https://doi.org/10.1016/j.cell.2008.11.006