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Confounding effect of obstructive jaundice in the interpretation of proteomic plasma profiling data for pancreatic cancer.
- Source :
-
Journal of proteome research [J Proteome Res] 2009 Jan; Vol. 8 (1), pp. 142-8. - Publication Year :
- 2009
-
Abstract
- It is well established that variation in sampling, processing and storage protocols can alter the levels of potential biomarkers in serum and plasma. Here, using pancreatic cancer as an example, we demonstrate that consideration of clinical parameters related to the patient's illness is equally important when seeking cancer-specific biomarkers. Bile duct-obstruction is a feature of pancreatic disease that can cause jaundice. Comparing patients with pancreatic cancer, chronic pancreatitis or biliary duct obstruction, we observed that the plasma levels of apolipoprotein A1, transthyretin, and apolipoprotein E, when examined in isolation, were each associated with pancreatic cancer. However, when the effect of bile duct obstruction was considered, only transthyretin levels were independently associated with cancer likelihood. Our results demonstrate the importance of accounting for disease-related confounding factors when analyzing data for the detection of cancer biomarkers.
- Subjects :
- Aged
Aged, 80 and over
Biomarkers, Tumor
CA-19-9 Antigen biosynthesis
Cholestasis blood
Cholestasis complications
Cholestasis diagnosis
Electrophoresis, Gel, Two-Dimensional
Female
Humans
Jaundice, Obstructive complications
Male
Middle Aged
Pancreatic Neoplasms complications
ROC Curve
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Jaundice, Obstructive blood
Jaundice, Obstructive diagnosis
Pancreatic Neoplasms blood
Pancreatic Neoplasms diagnosis
Proteomics methods
Subjects
Details
- Language :
- English
- ISSN :
- 1535-3893
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of proteome research
- Publication Type :
- Academic Journal
- Accession number :
- 19055369
- Full Text :
- https://doi.org/10.1021/pr800451h