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Increased plasma kynurenine values and kynurenine-tryptophan ratios after major trauma are early indicators for the development of sepsis.
- Source :
-
Shock (Augusta, Ga.) [Shock] 2009 Jul; Vol. 32 (1), pp. 29-34. - Publication Year :
- 2009
-
Abstract
- Kynurenine, the major degradation product of tryptophan has been shown to directly damage tissues, but its possible contribution to posttraumatic morbidity is unknown. Here, we studied the kinetics of kynurenine in patients after major trauma and whether this correlates with the development of posttraumatic sepsis. Kynurenine and tryptophan levels of 60 multiple-injured patients with Injury Severity Score of more than 16 were quantified prospectively by high-performance liquid chromatography. Blood samples were obtained daily from admission until day 10 after admission. Significantly increased kynurenine values were detectable already at day 1 after admission in blood from patients who later developed sepsis, regardless of injury pattern (P < 0.01). In contrast, kynurenine values of nonsepsis patients remained low throughout the observation period. However, all patients exhibited significantly decreased tryptophan values versus healthy controls (P < 0.01). Moreover, significantly increased kynurenine-tryptophan ratios rapidly predicted subsequent sepsis, multiple organ failure, and death (P < 0.01). Both increased kynurenine values and kynurenine-tryptophan ratios predicted posttraumatic development of sepsis and organ failure. This ought to be validated in subsequent studies.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Injury Severity Score
Kinetics
Male
Middle Aged
Multiple Organ Failure blood
Multiple Organ Failure etiology
Sepsis etiology
Time Factors
Young Adult
Kynurenine blood
Sepsis blood
Tryptophan blood
Wounds and Injuries blood
Wounds and Injuries physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-0514
- Volume :
- 32
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Shock (Augusta, Ga.)
- Publication Type :
- Academic Journal
- Accession number :
- 19060785
- Full Text :
- https://doi.org/10.1097/SHK.0b013e31819714fa