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Intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with dilated cardiomyopathy.
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2009 Aug; Vol. 13 (5), pp. 620-3. Date of Electronic Publication: 2009 Nov 26. - Publication Year :
- 2009
-
Abstract
- DCM is the most common cardiomyopathy in childhood. Effectiveness of anticongestive therapy is limited in most cases and about one-third of children diagnosed with DCM die or receive heart transplantation within the first year after diagnosis. Cardiac stem cell transplantation has become a promising therapy to treat heart failure in adult patients. Based on these promising results, the cardiac stem cell therapy might also represent a new therapeutic option particularly in young children. The present case documents for the first time intracoronary administration of autologous bone marrow-derived progenitor cells in a critically ill two-yr-old child with severe heart failure caused by DCM. Because of progressive worsening of the clinical condition despite maximal anticongestive treatment, the decision to perform autologous stem cell therapy was made. Cardiac stem cell therapy proved to be technically feasible, was associated with improvement in cardiac function, and might represent an option before heart transplantation in children with severe heart failure.
- Subjects :
- AC133 Antigen
Antigens, CD biosynthesis
Antigens, CD34 biosynthesis
Bone Marrow Cells cytology
Child, Preschool
Coronary Vessels pathology
Disease Progression
Glycoproteins biosynthesis
Heart Failure
Humans
Leukocyte Common Antigens biosynthesis
Male
Peptides
Treatment Outcome
Bone Marrow Transplantation methods
Cardiomyopathy, Dilated complications
Cardiomyopathy, Dilated physiopathology
Heart Transplantation methods
Stem Cells cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3046
- Volume :
- 13
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 19067928
- Full Text :
- https://doi.org/10.1111/j.1399-3046.2008.01024.x