Back to Search
Start Over
Ultrastructural study of the myocardium using cardioplegic crystalloid solution with and without procaine in patients undergoing aortic valve replacement.
- Source :
-
Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular [Rev Bras Cir Cardiovasc] 2008 Jul-Sep; Vol. 23 (3), pp. 389-95. - Publication Year :
- 2008
-
Abstract
- Objective: The aim of this study was to assess whether the presence of procaine in crystalloid cardioplegic solution increases myocardial protection at the ultra structural level.<br />Methods: Eighteen patients that underwent aortic valve replacement in the Hospital de Clínicas de Porto Alegre over a 10-month period were studied. They were randomly allocated into two groups: group A--eight patients receiving cardioplegia without procaine; group B--ten patients receiving cardioplegia with procaine. Myocardial biopsies were performed in three different periods: 1st--before ischemic arrest, 2nd--at the end of ischemic arrest, and 3rd--15 minutes after reperfusion.<br />Results: The ultra structural analysis comparing the groups in the three moments did not show any statistically significant difference. The mean score in group A at moment I, II and III was 0.1 +/- 0.2; 0.4 +/- 0.3; 0.4 +/- 0.4, and group B 0.2 +/- 0.2; 0.4 +/- 0.3; 0.7 +/- 0.2. Comparative analysis of CK-MB was similar. The spontaneous return to sinus rhythm after aortic declamping in group B occurred in 70% and in group A 12.5% (p=0.024).<br />Conclusion: Both cardioplegic solutions tested were equally effective in myocardial preservation, and we could not demonstrate at the ultrastructural level any benefit when procaine was added. The spontaneous return to sinus rhythm after aortic declamping was significantly greater when procaine was added.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Anesthetics, Local pharmacology
Chi-Square Distribution
Crystalloid Solutions
Female
Heart Arrest, Induced methods
Heart Conduction System physiopathology
Humans
Isotonic Solutions pharmacology
Male
Middle Aged
Myocardium enzymology
Remission, Spontaneous
Time Factors
Young Adult
Aortic Valve surgery
Cardioplegic Solutions pharmacology
Heart Valve Diseases surgery
Myocardial Reperfusion Injury prevention & control
Myocardium ultrastructure
Procaine pharmacology
Subjects
Details
- Language :
- English; Portuguese
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular
- Publication Type :
- Academic Journal
- Accession number :
- 19082329
- Full Text :
- https://doi.org/10.1590/s0102-76382008000300017